马来酰化壳聚糖的制备及其在透析纸中的应用

Preparation of Maleoyl Chitosan and Its Application in Dialysis Paper

本研究以壳聚糖(CS)和马来酸酐(MA)为主要原料,通过TEMPO氧化法制备马来酰化壳聚糖(MAAC),并将其作为添加剂用于透析纸的制备。探究了CS和MA质量比对MAAC取代度及溶解度的影响,以及MAAC用量对透析纸物理性能、透气性和抗菌性的影响。结果表明,当m(CS)∶m(MA)∶m(TEMPO)=1∶1.0∶0.08时,MAAC的取代度较高且溶解性较好;在中性和碱性条件下,溶液透光率大于80%。当MAAC用量为2.0%时,透析纸的干、湿抗张指数和撕裂指数分别提高了10.0%、96.8%和20.3%,透气度达8.98μm/(Pa·s),并具有良好的抗菌性。

In this study, chitosan(CS) and maleic anhydride(MA) were used as the main raw materials to prepare maleoyl chitosan(MAAC)via TEMPO oxidation. The dialysis paper was prepared with the MAAC as the additives. The effects of the mass ratio of CS and MA on the substitution degree and solubility of the MAAC were studied, and the effects of MAAC dosage on the physical properties, air permeability and antibacterial properties of dialysis paper were also investigated. The results showed that the substitution degree of MAAC was higher and the solubility was better when the mass ratio of CS, MA and TEMPO was 1∶1. 0∶0. 08, and the light transmittance of the solution was greater than 80% under neutral and alkaline conditions. The dry and wet tensile index and tear index of dialysis paper after adding 2. 0%MAAC were increased by 10. 0%, 96. 8% and 20. 3%, respectively. The air permeability of dialysis paper after adding 2. 0% MAAC reached 8. 98 μm/(Pa·s), with a good antibacterial property.