Deciphering neural circuits mediating sound-induced analgesia

Pain is one of the most common clinical symptoms and a leading cause of disability worldwide(GBD 2016 Disease and Injury Incidence and Prevalence Collaborators,2017).Furthermore,pain is closely associated with various emotional disorders,including anxiety and depression,which may,in turn,heighten pain intensity and prolong its duration(Bair et al.,2003).In previous studies,we identified the neural circuits underlying chronic pain-induced depression and anxiety as well as depression-induced allodynia(Zhou et al.