预后营养指数对雄激素剥夺治疗前列腺癌患者预后的预测价值

Predictive Value of Prognostic Nutritional Index on the Prognosis of Prostate Cancer Patients Treated with Androgen Deprivation

目的 分析预后营养指数(prognostic nutritional index, PNI)对雄激素剥夺治疗前列腺癌患者预后的预测价值。方法 回顾性分析2016年1月—2019年1月南通大学附属如皋医院收治的86例雄激素剥夺治疗前列腺癌患者的临床资料,纳入观察组;另选择86名体检健康受试者,纳入对照组。随访观察组3年,根据生存结局将其分为生存组与死亡组,比较两组PNI及NLR值。计算PNI及NLR值预测雄激素剥夺治疗前列腺癌患者的预后价值。结果 观察组PNI值低于对照组,NLR值高于对照组,差异有统计学意义(P<0.05)。生存组患者PNI值为(49.68±2.01),高于死亡组,NLR值为(2.45±0.33),低于死亡组,差异有统计学意义(t=7.805、11.133,P<0.05)。PNI及NLR对死亡诊断最佳截断值分别是37.54、4.26,AUC分别是0.634(95%CI:0.524~0.718)、0.687(95%CI:0.589~0.778),灵敏度分别是56.69%、46.68%,特异度分别是74.15%、94.58%。结论 PNI较常规NLR在预测雄激素剥夺治疗前列腺癌患者预后上价值更高,临床建议推广。

Objective To analyze the predictive value of prognostic nutritional index(PNI) on the prognosis of prostate cancer patients treated with androgen deprivation. Methods A retrospective analysis of 86 patients with androgen deprivation therapy for prostate cancer admitted to the Rugao Hospital Affiliated to Nantong University from January 2016 to January 2019 was included in the observation group. Another 86 people of healthy subjects with physical examination were selected and included in the control group. Patients in the observation group will be followed up for 3years. Patients will be grouped into survival and death groups according to outcome of survival, PNI and NLR values will be compared between the two groups. PNI and NLR were calculated to predict the prognostic value of androgen deprivation therapy in prostate cancer patients. Results The PNI value of patients in the observation group was lower than that of the control group, and the NLR value was higher than that of the control group, the difference was statistically significant(P<0.05). Patients in the survival group had higher PNI values(49.68±2.01) than the death group, and lower NLR values(2.45±0.33) than the death group, the difference was statistically significant(t=7.805, 11.133, P<0.05). The best cut-off values of PNI and NLR for death diagnosis were 37.54, 4.26, and AUC were 0.634(95%CI:0.524-0.718) and 0.687(95%CI: 0.589-0.778), respectively, with the sensitivities of 56.69% and 46.68%, the specificities of 74.15% and 94.58%, respectively. Conclusion PNI is more valuable than conventional NLR in predicting the prognosis of prostate cancer patients treated with androgen deprivation, and its worthy of clinical promotion.