化疗诱导的周围神经病变患者多模式运动干预

Effectiveness of multimodal exercise in colorectal cancer patients with chemotherapy-induced peripheral neuropathy

目的探讨多模式运动在化疗诱导的周围神经病变患者中的应用效果。方法便利抽取82例结直肠癌化疗诱导的周围神经病变患者,按病区分为对照组和干预组各41例。对照组采用步行运动,每次30 min,每周至少3次;干预组采用多模式运动干预,每次30~40 min,每周至少3次。干预前及干预12周,采用化疗诱导的周围神经病变评估工具、Berg平衡量表、修正版跌倒效能量表、起立-行走计时测试进行效果评价。结果对照组38例、干预组36例完成研究。干预12周后,干预组患者化疗诱导的周围神经病变得分、Berg平衡得分<45分发生率、起立-行走计时测试结果显著低于对照组,跌倒自我效能得分显著高于对照组(均P<0.05)。结论多模式运动有利于改善结直肠癌患者化疗诱导的周围神经病变症状体验及对日常生活能力的影响,提高患者的平衡功能、跌倒自我效能和移动能力。

Objective To investigate the effect of multimodal exercise in colorectal cancer patients with chemotherapy-induced peripheral neuropathy(CIPN).Methods A total of 82 colorectal cancer patients with CIPN were conveniently selected and divided into a control group and an intervention group,with 41 in each group.The control group was asked to walk for 30 min per session,at least 3 sessions per week.The intervention group received multimodal exercise with a time commitment of 30-40 min per session,at least 3 sessions per week.The CIPN Assessment Tool(CIPNAT),Berg Balance Scale(BBS),Modified Falls Efficacy Scale(MFES),and Timed Up and Go Test(TUGT)were utilized to compare the effect between the two groups before and after 12-week intervention.Results Thirty-eight in the control group and 36 in the intervention group completed the study.After 12 weeks of intervention,the CIPNAT score,the incidence of BBS score<45,and TUGT test result were significantly lower,whereas MFES score was significantly higher in the intervention group compared with the control group(all P<0.05).Conclusion Multimodal exercise can alleviate symptom experience of CIPN and its impact on daily living in colorectal cancer patients,and enhance their balance function,falls self-efficacy and mobility.