小腿围筛查稳定期男性COPD患者骨骼肌消耗研究

Calf circumference for predicting skeletal muscle wasting in male patients with chronic obstructive pulmonary disease

目的探讨小腿围筛查稳定期男性COPD患者骨骼肌消耗的效果,为早期识别骨骼肌消耗高危患者提供参考。方法对116例门诊就诊的稳定期男性COPD患者进行小腿围测量,并采用生物电阻抗法评价患者的骨骼肌消耗情况。采用ROC曲线下面积确定小腿围的最佳截点值。结果6.90%的男性COPD患者有骨骼肌消耗;116例COPD患者小腿围(34.58±3.03)cm,小腿围与四肢骨骼肌质量、四肢骨骼肌质量指数呈显著正相关(均P<0.05)。小腿围预测稳定期男性COPD患者骨骼肌消耗的最佳截点值为31.8 cm(灵敏度1.000、特异度0.861、ROC曲线下面积0.963),经调整年龄后,ROC曲线下面积提高为0.973。结论小腿围可作为稳定期男性COPD患者骨骼肌消耗筛查的有效方法。

Objective To determine if calf circumference(CC)could predict skeletal muscle wasting in male patients with stable COPD,and to provide reference for early identification of high-risk patients.Methods A total of 116 male patients attending outpatient clinic were recruited.CC was measured and skeletal muscle wasting was evaluated by bioelectrical impedance analysis.The optimal cut-off value of CC was obtained by the receiver operating characteristic curve.Results Approximately 6.90%male COPD patients had skeletal muscle wasting.CC of 116 COPD patients averaged(34.58±3.03)cm.CC was positively correlated with the appendicular skeletal muscle mass(ASM)and the ASM index(both P<0.05).The optimal cut-off value of CC for predicting skeletal muscle wasting was 31.8 cm(with the sensitivity of 1.000,the specificity of 0.861,and the AUC of 0.963).After adjusting for age,the AUC was enhanced to 0.973.Conclusion CC is a useful tool for screening skeletal muscle wasting in male patients with stable COPD.