施万细胞在恶性肿瘤进展中的作用

Role of Schwann cells in the progress of malignant tumors

施万细胞(Schwann cells,SCs)是外周神经系统中最重要的神经胶质细胞类型,在神经损伤修复过程中起重要作用。近年来研究显示,SCs作为连接神经和肿瘤细胞的“桥梁分子”,通过与肿瘤细胞、免疫细胞、间质细胞等相互作用,改善局部肿瘤微环境,进而促使肿瘤嗜神经生长和神经支配、促进肿瘤的生长、迁移和侵袭,产生免疫抑制并出现肿瘤疼痛等一系列恶性生物学行为。本文就SCs在非神经肿瘤中的作用及其机制进行综述,以期为将来抗肿瘤治疗联合靶向SCs的治疗策略提供理论基础。

Schwann cells(SCs)are the most important glial cell type in the peripheral nervous system and play an important role in nerve injury repair.In recent years,studies have shown that SCs act as the bridge between nerves and tumor cells.By connecting with tumor,immune,and mesenchymal cells,they regulate the local tumor microenvironment,enhance perineural tumor growth and innervation,and promote tumor growth,migration,and invasion,producing immune suppression and tumor pain and a series of malignant biological behavior.This article reviews the role and mechanism of SCs in non-neurologic tumors to provide a theoretical basis for future treatment strategies of anti-tumor therapy combined with SC targeting.