乙肝肝硬化门静脉高压患者磁共振肝脏T1弛豫时间与肝静脉压力梯度的相关性分析

Correlation between relaxation time T1 and hepatic venous pressure gradient in Hepatitis B cirrhosis patients with portal hypertension

目的 探讨MRI肝脏T1弛豫时间在乙肝肝硬化门静脉高压患者中与肝静脉压力梯度(HVPG)相关性。方法 选取本院接治的92例乙肝肝硬化患者的临床资料,以HVPG值划分为高压组和对照组。其中以HVPG>5 mmHg为高压组(n=60),以HVPG<5 mmHg为对照组(n=32)。分析两组一般临床资料、生化指标、凝血酶原时间、肝脏T1弛豫时间、肝脏硬度检测(LSM)及增强肝纤维化(ELF)评分,分析肝硬化门静脉高压患者肝脏T1弛豫时间与HVPG的关系。结果 高压组患者凝血酶原时间、肝脏T1弛豫时间长于对照组,差异均有统计学意义(P<0.05);此外,高压组患者LSM、ELF评分及HVPG均明显高于对照组,差异均有统计学意义(P<0.05);高压组肝脏T1弛豫时间与HVPG均呈正相关(r=0.533,P<0.05)。结论 乙肝肝硬化门静脉高压患者肝脏T1弛豫时间联合其他指标可代替HVPG,用于无创检测乙肝肝硬化门静脉高压,适合临床推广。

Objective To explore the correlation between relaxation time T1of MRI and hepatic venous pressure gradient(HVPG) in Hepatitis B cirrhosis patients with portal hypertension. Methods The clinical data of 92 patients with hepatitis B cirrhosis treated were retrospectively analyzed. They were divided into high pressure group and control group according to HVPG value. Among them, HVPG > 5 mmhg was the high-pressure group(n=60), and HVPG < 5 mmhg was the control group(n=32). The clinical data, biochemical indexes, prothrombin time, relaxation time T1, liver stiffness measurement(LSM) and enhanced liver fibrosis(ELF) score were collected and analyzed. The relationship between relaxation time T1and HVPG was analyzed. Results Prothrombin time and relaxation time T1of liver in high-pressure group were significantly longer than those in control group(P<0.05);In addition, the LSM, ELF score and HVPG of the high-pressure group were significantly higher than those of the control group(P<0.05);There was a positive correlation between relaxation time T1and HVPG(r=0.533, P<0.05). Conclusion Liver relaxation time T1combined with other indicators can replace HVPG in hepatitis B cirrhosis patients with portal hypertension. It is suitable for non-invasive detection of hepatitis B cirrhosis patients with portal hypertension and is suitable for clinical promotion.