微量元素硒在对抗COVID-19中的作用研究进展

Narrative Review on the Roles of Selenium Against COVID-19

自新型冠状病毒肺炎(corona virus disease 2019,COVID-19)疫情爆发以来,严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)引起的各类临床表现和后续并发症受到了广泛关注。有研究发现,COVID-19死亡率具有地域差异性,中度或重度缺硒地区感染人群常常具有更高的死亡率,因此硒可能在对抗COVID-19中具有一定的作用。总结了硒缺乏COVID-19患者的临床表现、硒对抗COVID-19的临床效应、以及硒对抗COVID-19的作用机制等方面的研究进展。从目前的研究结果来看,硒在应对感染SARS-CoV-2以及避免过激免疫反应导致的细胞因子风暴过程中具有积极作用,但仍然缺乏临床试验研究证据。

Since the outbreak of corona virus disease 2019(COVID-19)in 2019,the symptoms and complications caused by severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)have received much attention.Some studies have found that the case fatality rate varies among the different areas,in which moderate or severe selenium(Se)deficiency areas had higher case fatality rates,indicating Se might play some roles during development of COVID-19.The symptoms of Se deficient COVID-19 patients,the use of Se supplements in COVID-19 treatment and the possible mechanism of Se against COVID-19 were summarized through a systematic literature review.From current outcomes,Se could play positive roles in adjusting the immune system and relieving inflammation,which could help avoid the cytokine storm,but need more clinical studies to verify.