不同治疗方法对前列腺癌合并房颤的影响 及预防策略研究进展

Research Progress on Effects of Different Treatments on Prostate Cancer with Atrial Fibrillation and Prevention Strategies

心房颤动(AF)是临床上最常见的心律失常。随着人口老龄化,发病率呈逐年上升趋势。AF风险增加的相关危险因素包括老年、肥胖、糖尿病、高血压和癌症等。研究表明,在所有年龄组中,伴发AF癌症患者的死亡率、住院费用和住院时间均高于非AF患者。前列腺癌(PCa)患者全身炎性反应增加、电解质异常和神经激素变化,导致其AF发生率明显高于其他癌症。前列腺癌手术、化疗和放疗也可能增加AF的风险。本综述系统收集相关文献,了解PCa患者发生AF的机制,确定PCa与AF之间的关系及其对住院预后的影响,为防治PCa患者发生AF提供策略。

Atrial fibrillation(AF)is one of the most common clinical arrhythmias.As the population ages,there is an upward trend in its prevalence.The risk factors associated with increased risk of AF include old age,diabetes,hypertension,and cancer.Studies have shown that in all age groups,the risk of death,hospitalization expenses,and hospitalization time of cancer patients with AF were higher than that without AF.Thus,increased systemic inflammation,electrolyte abnormalities,and neurohormonal changes in patients with prostate cancer(PCa)lead to a significantly higher incidence of AF than other cancers.However,the treatment of prostate cancer,including surgery,chemotherapy and radiotherapy,may also increase the risk of AF.In this review,relevant literatures are collected to understand the mechanism of AF in patients with PCa,determine the relationship between PCa and AF and its effect on hospitalized prognosis,and provide strategies for the prevention and treatment of AF in patients with PCa.