海军潜艇官兵代谢指标与肠道菌群关联研究

Study on the relationship between metabolic indexes and gut microbiota in Naval personnel onboard the submarine

目的 调查某部海军潜艇官兵代谢性疾病的患病情况,并探讨其与肠道菌群多性性的关联。方法 随机抽取某部潜艇官兵30名作为研究组,选取年龄和体重指数(BMI)匹配的健康体检30人作为对照组,进行代谢指标检测及粪便肠道菌群多样性分析。结果 研究组舒张压低于对照组,而血尿酸、血红蛋白及总胆固醇(TC)等代谢指标均高于对照组(P<0.05)。2组肠道菌群在各细菌学分类水平差异有统计学意义(P<0.05)。研究组肠道菌群中的厚壁菌门、栖粪杆菌属和普氏栖粪杆菌丰度高于对照组,拟杆菌门、变形菌门则低于对照组(P<0.05)。其中拟杆菌属丰度与BMI和TC水平均呈现负相关,栖粪杆菌与血尿酸及TC水平呈现正相关(P<0.05)。结论 血尿酸、TC等代谢指标在海军潜艇官兵中有增高趋势,且与特定肠道菌群结构多样性改变有一定关联。

Objective To investigate the prevalence of metabolic diseases and the relationship with gut microbiota in Naval personnel onboard the submarine.Methods Thirty submariners from a certain Naval unit were randomly selected for study, and another 30 healthy adults from the hospital with similar age and body mass indexn(BMI) were recruited as the control group.Metabolic indexes and fecal intestinal flora diversity were detected in all the subjects.Results Compared with those of the healthy control group, the diastolic pressure of the submarinersl was slightly lower, while metabolic indexes such as blood uric acid, hemoglobin and total cholesterol(TC) were all higher than those of the control group(P<0. 05). There were some differences in the levels of bacteriological classification, when comparisons were made between the two groups(P<0. 05). The abundance of Firmicutes, Faecalibacterium and Faecalibacterium-prausnitzii in the intestinal flora of the submariners were significantly higher than those of the control group, while Bacteroidetes and Proteobacteria were significantly lower than those of the control group. The abundance of Bacteroides were negatively correlated with BMI and TC levels, and Faecalibacterium level was positively correlated with those of serum uric acid and TC(P<0. 05).Conclusion Such metabolic indexes as blood uric acid and TC displayed an increasing tendency among the submariners, and was to a certain extent correlated with the structural diversity of specific gut microbiota.