某制鞋厂一起混合性气体致中毒性肝病7例报告

A report of 7 cases of toxic liver disease caused by mixed gas in a shoe factory

三氯甲烷、二氯甲烷对肝脏具有毒性作用,其所致中毒性肝病事件时有报道。2021年11月广东省惠东县某鞋厂发生一起职业性化学中毒事件,经检测现场空气、分析中毒患者临床资料,初步判定为以三氯甲烷为主的混合性气体中毒事故所导致的中毒性肝病。7名患者入院时检测肝功能不同程度受损表现(丙氨酸氨基转移酶145~2501 IU/L,天门冬氨酸氨基转移酶66~1286 IU/L);对现场原辅材料进行挥发性有机成分分析,中毒现场粉胶车间使用103A粉胶检出三氯甲烷百分比含量占21.11%、二氯甲烷百分比含量占6.77%。

Trichloromethane and dichloromethane have toxic effects on the liver,and incidents of toxic liver disease caused by them have been reported from time to time.In November 2021,an occupational chemical poisoning incident occurred in a shoe factory in Huidong County,Guangdong Province.After testing the air at the scene and analyzing the clinical data of the poisoning patients,it was preliminarily determined that the poisoning was caused by a mixed gas poisoning incident dominated by trichoromethane.At admission,the liver function of 7 patients was tested for different degrees of impairment(alanine aminotransferase 145-2501 IU/L,aspartate aminotransferase 66-1286 IU/L).The volatile organic components of on-site raw and auxiliary materials were analyzed.The percentages of trichloromethane and dichloromethane detected in 103A powder glue used in the poisoning workshop site accounted for 21.11%and 6.77%respectively.