放射性^(125)I粒子在肺腺癌EMT及临床治疗中的作用

The Role of Radioactive Iodine-125 Particles in EMT and Clinical Treatment of Lung Adenocarcinoma

肺癌是最常见的肿瘤之一,而云南省肺癌的发病率位居全国首位。许多患者确诊时已为晚期肺癌,采用多手段联合治疗,包括化学治疗、放射治疗、靶向治疗、免疫治疗以及局部治疗(消融、冷冻、^(125)I等)。放射性^(125)I粒子植入治疗作为晚期肺癌局部治疗手段之一,有其独特的优势,其放射半径小,特异性照射靶向病灶,而对周围正常组织损伤小,并且临床效果较好。研究表明上皮-间质样表型转化(epithelial-mesenchymal transformation,EMT)与肺腺癌的生长、侵袭、转移密切相关。对放射性^(125)I粒子在肺腺癌EMT及临床治疗中的作用进行论述。

Lung cancer is one of the most common tumors,and Yunnan has the highest incidence of lung cancer in China.Many patients are diagnosed with advanced lung cancer and are treated with a combination of chemotherapy,radiotherapy,targeted therapy,immunotherapy,and local therapy( ablation,freezing,^(125)I,etc.).As one of the local treatment methods for advanced lung cancer,radioactive ^(125)I seed implantation has its unique advantages,such as small radiation radius,specific irradiation targeting of the lesion,and little damage to surrounding normal tissue,and good clinical effect.Studies have shown that epithelial mesenchymaltransformation(EMT) with lung adenocarcinoma is closely related to the growth,invasion,and metastasis.This article discusses the role of radioactive ^(125)I particles in EMT and clinical treatment of lung adenocarcinoma.