摘要
To the Editor:Type 1 diabetes(T1D)is caused by autoimmunity-mediated destruction of pancreatic islet beta cells,with islet autoimmunity being the essential component in the pathogenesis of T1D.[1]However,studies on human islets are limited due to sampling difficulties.Therefore,immunological changes in peripheral blood mononuclear cells(PBMCs)should be emphasized.In one way,islet-infiltrating immune cells are presumably in equilibrium with circulating pools and changes in PBMCs might partly reflect islet inflammation.On the other,PBMCs represent a useful tool to detect biomarkers for disease.[2]Traditionally,studies on PBMCs in T1D are characterized by the use of limited numbers of cell-surface markers and secreted cytokines measured using flow detection and other antibody-based assays.
基金
National Natural Science Foundation of China(No. 82070812)
Fundamental Research Funds for the Central Universities of Central South University(No. 2021zzts0361)
Hunan Provincial Innovation Foundation for Postgraduate(No. CX20210363)
