Dynamic changes of wound-related miRNAs after application of autologous platelet-rich gel in diabetic wounds

To the Editor:Diabetic chronic cutaneous ulcers(DCUs)are among the most common and serious complications of diabetes mellitus.Diabetic foot ulcers are the most common type of DCU and are now considered a global epidemic.[1]The clinical prevention and treatment of DCUs are critical and have remained challenging for clinicians.With the exploration of topical treatment methods,autologous platelet-rich gel(APG)is regarded as an adjuvant therapy to promote wound healing,and it has been widely used for wound repair.[2]Some microRNAs that play a critical role in the whole wound healing process have been found in wound tissues,which we call wound-related miRNAs(wr-miRNAs).However,few studies have explored the dynamic changes of wr-miRNAs during APG treatment.Our study aimed to evaluate the efficacy of APG in treating diabetic wounds and explore the dynamic changes of wr-miRNAs during wound healing.