帕金森病合并新型冠状病毒感染治疗药物的相互作用

Drug interactions in the treatment of Parkinson disease with corona virus disease 2019

帕金森病患者合并新型冠状病毒感染(COVID-19)时,其治疗药物合用的安全性问题受到广泛关注。利物浦药物相互作用数据库、Up To Date数据库的相关数据及国内外药品说明书和指南等有助于评估帕金森病与COVID-19治疗药物之间的相互作用以及其影响程度。本文结合药物的代谢和排泄途径,就帕金森病合并COVID-19治疗药物的相互作用进行概述。

In patients with Parkinson disease complicated with corona virus disease 2019(COVID-19),the safety of drug combination has been widely concerned.The Liverpool COVID-19 Drug Interactions database,Up To Date database,domestic and international drug package inserts,and guidelines,have provided much information for clinicians to assess the in?teraction between Parkinson medications and COVID-19 medications as well as the extent of their impact.In this paper,the drug interaction in treating Parkinson disease with COVID-19 in combination with drug metabolism and excretion pathways were summarized.