低分子量肝素联合阿司匹林治疗进展性脑梗死45例疗效观察

Effect of Low Molecular Weight Heparin Combined with Aspirin On 45 Patients with Progressive Cerebral Infarction

目的:探究低分子量肝素联合阿司匹林在治疗进展性脑梗死中的临床价值。方法:纳入萍乡市人民医院2019年1月至2021年6月收治的90例进展性脑梗死患者,按随机数字表法分为对照组(n=45例)和观察组(n=45例)。对照组予阿司匹林肠溶片治疗,观察组在此基础上予以低分子量肝素治疗,2周后比较两组治疗效果、凝血功能及不良反应。结果:观察组治疗总有效率为97.78%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗前,两组凝血功能比较,差异无统计学意义(P>0.05);治疗后,观察组纤维蛋白原(FIB)水平为(2.23±0.48)g/L低于对照组,活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及凝血酶时间(TT)分别为(24.72±3.41)s、(12.54±0.78)s、(12.43±1.52)s均长于对照组,神经功能评分为(7.80±1.39)分低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低分子量肝素配合阿司匹林肠溶片治疗进展性脑梗死可减轻神经损伤,改善凝血功能,不良反应少,安全可靠。

Objective:To explore the clinical effect of low molecular weight heparin combined with aspirin in the treatment of progressive cerebral infarction.Methods:90 patients with progressive cerebral infarction admitted to Pingxiang People's Hospital from January 2019 to June 2021 were randomly divided into control group(45 cases)and observation group(45 cases).The control group was treated with aspirin enteric coated tablets,and the observation group was treated with low molecular weight heparin on this basis.Two weeks later,the treatment effect,coagulation function and adverse reactions of the two groups were compared.Results:The total effective rate of the observation group was 97.78%,higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in coagulation function between the two groups(P>0.05).After treatment,the fibrinogen(FIB)level of the observation group was(2.23±0.48)g/L lower than that of the control group,and the activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)were(24.72±3.41)s,(12.54±0.78)s,(12.43±1.52)s longer than that of the control group,and the neurological function score was(7.80±1.39)points lower than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Low molecular weight heparin with aspirin enteric coated tablets in the treatment of progressive cerebral infarction can reduce nerve damage,improve coagulation function,have less adverse reactions,and is safe and reliable.