癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展

Research progress of generalized electroencephalography suppression after epileptic seizure as an electroencephalography marker of sudden unexpected death in epilepsy

目前尚缺乏可靠的癫痫猝死(SUDEP)预测指标,给癫痫患者的生命安全造成巨大威胁。随着研究深入,癫痫发作特别是全面性强直-阵挛发作后,脑电图可监测到癫痫发作后全面性脑电抑制(PGES),自此PGES作为SUDEP可能的脑电图标志物备受关注。本文拟对PGES病理生理学机制、相关因素及最新研究进展进行综述,分析PGES的产生及其与SUDEP的关联性。

At present,there is a lack of reliable prediction index for sudden unexpected death in epilepsy(SUDEP),which poses a great threat to the lives of patients with epilepsy.With the deepening of research,it has been found that postictal generalized electroencephalography suppression(PGES)occurs in EEG monitoring after seizure,especially generalized tonic-clonic seizure(GTCS).Since then,PGES has attracted much attention as a possible EEG marker of SUDEP.Combined with the study of the pathophysiological mechanism,related factors of PGES phenomenon,and this paper further analyzes the relationship between the occurrence of PGES and SUDEP.