ADM、TfR1、VEGF在骨肉瘤组织中的表达及其对患者预后判断的价值

Expression of ADM,TfR1 and VEGF in Osteosarcoma Tissue and the Value of Prognostic Judgment of Patients

目的探讨ADM、TfR1、VEGF在骨肉瘤组织中的表达及其对患者预后判断的价值。方法收集骨肉瘤患者60例,所有患者均同意手术治疗,且术中获取癌组织及癌旁组织。观察ADM、TfR1、VEGF在骨肉瘤组织中的表达及与临床病理参数的关系,同时观察患者预后与ADM、TfR1、VEGF表达的相关性。结果癌组织ADM、TfR1、VEGF表达(78.33%、73.33%、76.67%)均显著高于癌旁组织,差异均具有统计学意义(χ^(2)=48.348、34.286、51.400,P均<0.05)。骨肉瘤组织中ADM、TfR1、VEGF表达均与组织分化、是否转移以及Enneking分期有关(P<0.05),但与性别、肿瘤大小均无关(P>0.05)。ADM、TfR1、VEGF中高表达组患者2年累积存活率均显著低于低表达组(P<0.05)。ADM蛋白表达分别与TfR1、VEGF蛋白表达呈正相关(γ=0.621,γ=0.553,P均<0.05),TfR1蛋白表达与VEGF蛋白表达呈正相关(γ=0.671,P<0.05)。结论ADM、TfR1、VEGF在骨肉瘤组织中阳性表达率较高,且与骨肉瘤患者预后有关。

Objective To investigate the expression of ADM,TfR1 and VEGF in osteosarcoma tissues and their prognostic value.Methods A total of 60 patients with osteosarcoma were collected.All the patients agreed to be treated with surgery.To observe the expression of ADM,TfR1 and VEGF in osteosarcoma tissues and their relationship with clinicopathological parameters,and to observe the correlation between patient prognosis and the expression of ADM,TfR1 and VEGF.Results The expressions of ADM,TfR1 and VEGF in cancer tissues(78.33%,73.33%,76.67%)were significantly higher than those in para-cancer tissues,with statistical significance(χ^(2)=48.348,34.286,51.400,all P<0.05).The expression of ADM,TfR1 and VEGF in osteosarcoma tissues was correlated with tissue differentiation,metastasis and Enneking stage(P<0.05),but not with gender or tumor size(P>0.05).The 2-year cumulative survival rate in ADM,TfR1 and VEGF medium-high expression group was significantly lower than that in low-expression group(P<0.05).The protein expression of ADM was positively correlated with the protein expression of TfR1 and VEGF(γ=0.621,γ=0.553,both P<0.05),and the protein expression of TfR1 was positively correlated with the protein expression of VEGF(γ=0.671,P<0.05).Conclusion The positive expression rate of ADM,TfR1 and VEGF in osteosarcoma tissues is high,and it is related to the prognosis of osteosarcoma patients.