石家庄市肺癌患者生存分析

Survival analysis of lung cancer patients in Shijiazhuang city

目的:了解石家庄市肺癌患者生存情况。方法:对石家庄市2015年确诊的肺癌患者随访至2020年12月31日,运用寿命表法计算生存率和中位生存期,用对数秩检验(log-rank test)检验差别,采用Cox回归模型进行多因素分析。结果:纳入分析的肺癌患者1537例,平均年龄(66.80±11.46)岁,中位生存期为15.60个月,1年、3年、5年生存率分别为55.05%、38.25%、27.39%。不同性别、区域、年龄、TNM分级、组织学类型的肺癌患者5年生存率差异有统计学意义,5年生存率男性(21.99%)、农村(12.23%)、小细胞癌(13.49%)低于女性(31.99%)、城市(33.68%)和腺癌(40.06%),且随着年龄和TNM分级的增加而逐渐降低。Cox模型显示性别、区域、组织学类型、TNM分级是肺癌生存的独立影响因素,其中组织学类型和TNM分级对生存影响较大。结论:肺癌预后差,不同区域,不同人群需建立有差异的干预筛查机制,早预防、早筛查、早诊断、早治疗,有助于延长肺癌患者生存时间。

Objective:To study the survival state of lung cancer patients in Shijiazhuang city.Methods:Lung cancer patients diagnosed in Shijiazhuang in 2015 were followed up to December 31,2020.Survival rate and median survival time were calculated by life table method,and were tested by log-rank test.Cox regression analysis was used in the multivariate analysis.Results:All 1537 cases of lung cancer were included in the study.The average age of pa⁃tients was(66.80±11.46)years.The overall median survival time was 15.60 months.The 1-year,3-year,and 5-year survival rates were 55.05%,38.25%,27.39%.The survival rates were different with gender,area,age,TNM stage,histological type.The 5-year survival rates of male(21.99%),rural(12.23%)and small cell carcinoma(13.49%)was lower than that of female(31.99%),urban(33.68%)and adenocarcinoma(40.06%),survival rates decreased with the increasing of age and TNM stage.In Cox regression analysis,gender,area,histological type,TNM stage were independent prognostic factors.Histological type and TNM stage and greater influence on survival.Conclu⁃sion:The prognosis of lung cancer generally is poor.In different regions,screening mechanisms and health education should be strengthened for different people.Early prevention,early screening,early diagnosis and early treatment are helpful to prolong the survival time of lung cancer patients.