核糖体蛋白调控病毒生命周期的研究进展

Advances in Ribosomal Protein Regulation of Viral Life Cycle

病毒是一种基因组比较小,仅编码自身结构蛋白和一些重要的与复制相关的非结构蛋白的细胞内寄生物。为了完成其生命周期,它还需要劫持宿主细胞内的一些蛋白或细胞因子,以组装成病毒的复制或翻译机器。其中,核糖体蛋白(RPs)就是病毒经常劫持的一类宿主蛋白,被用来组装病毒的“翻译机器”。本文即对近年来关于RPs在病毒蛋白翻译中的调控作用研究进展做一综述。

The viruses, as intracellular parasites with small genomes, only encode structural proteins and some essential nonstructural proteins necessary for their replication. To complete viral life cycle, viruses also need to hijack some proteins or cytokines from host cells to assemble into viral replication or translation machines. Among of them, ribosomal proteins(RPs) as class of host proteins are often hijacked by viruses for assembly of viral “translation machines”. In a word, this paper reviewed the recent research on the regulation of RPs during viral life cycle.