恶性实体肿瘤患者输注不同贮存时间去白悬浮红细胞的价值评估

Evaluation of the value of transfusions of leukocyte-depleted suspended red blood cells for different storage duration in patients with malignant solid tumor

目的探讨恶性肿瘤患者输注不同贮存时间去白悬浮红细胞的临床价值,为临床提供参考。方法选取2021年1月至2022年7月邯郸市中心医院收治的80例恶性实体肿瘤患者为研究对象进行回顾性分析,以去白悬浮红细胞储存时间14 d为临界值,按照输注不同储存时间去白悬浮红细胞将患者分为观察组(输注储存时间在14 d以内去白悬浮红细胞)和对照组(输注储存时间超过14 d去白悬浮红细胞),各40例。比较两组患者去白悬浮红细胞中三磷酸腺苷、2,3二磷酸甘油酸水平及pH值,比较采集至储存间隔不同时间红细胞有效携氧量(Q)水平,比较两组患者输注2单位去白悬浮红细胞后血红蛋白(Hb)水平及红细胞比容变化情况。结果观察组患者三磷酸腺苷、2,3二磷酸甘油酸、pH值水平显著高于对照组(P<0.05);去白悬浮红细胞采集当日红细胞Q水平高于7、14、21、28 d,且去白悬浮红细胞采集时间在28 d及以上的红细胞有效携氧量水平最低(P<0.05);观察组患者输注2单位去白悬浮红细胞后Hb水平及红细胞比容水平均高于对照组(P<0.05)。结论恶性肿瘤患者输注存储时间在14 d以内的去白悬浮红细胞,能更有效提高机体Hb及红细胞比容水平,且具有更理想的有效携氧量。

Objective To explore the clinical value of leukocyte-depleted suspended red blood cells for different storage duration in patients with malignant solid tumors to provide reference for clinic.Methods 80 patients with malignant solid tumors treated in Handan Central Hospital between January 2021 and July 2022 were selected for retrospective analysis.Taking the storage duration of leucocyte depleted suspended red blood cells for 14 days as the critical value,the patients were divided into observation group(infused with leukocyte-depleted suspended red blood cells stored within 14 days)and control group(infused with the same kind of red blood cells stored for more than 14 days),including 40 patients in each group.The levels of adenosine triphosphate,2,3-diphosphoglyceric acid and pH in the leukocyte-depleted suspendedred blood cells of the two groups were compared,and the effective oxygen carrying capacity(Q)level of the red blood cells of different duration between collecting and storing was compared.The changes of hemoglobin level and hematocrit of the two groups were compared after 2 units of the leukocyte-depleted suspended red blood cells infusion.Results The levels of adenosine triphosphate 2,3-diphosphoglyceric acid and pH in the observation group were significantly higher thant hose in the control group(P<0.05).The Q level on the day of collecting leukocyte-depleted suspended red blood cells was higher than that after 7,14,21 and 28 days,and the Q level of the red blood cells was the lowest when the duration of leukocyte-depleted suspended red blood cells storage was 28 days or more(P<0.05).Hemoglobin level and hematocrit of observation group were higher than those of the control group after 2 units of leukocyte-depleted suspended red blood cells infusion(P<0.05).Conclusion Infusion of leucocyte-depleted suspended red blood cells stored for less than 14 days for patients with malignant tumor can effectively improve the level of hemoglobin and hematocrit,and has more ideal Q level.