Th2及Th17相关细胞因子在慢性自发性荨麻疹发病机制中的作用研究进展

Research progress on the role of Th2 and Th17-related cytokines in the pathogenesis of chronic spontaneous urticaria

慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)在临床上是一种常见的过敏性皮肤病,发病机制复杂,目前仍未充分阐明。近年较受关注的是辅助性T淋巴细胞1(helper T lymphocyte 1,Th1)/Th2细胞因子失衡学说,其中Th2细胞因子可直接或间接诱发变态反应性疾病,其异常分泌与CSU的发生发展及预后关系密切。此外,近年来Th17细胞因子也备受关注,越来越多的证据表明其对CSU具有重要作用,针对相关细胞因子的药物治疗也取得前所未有的进展。本文综述了Th2和Th17相关细胞因子在CSU发生发展中的作用,为后续研究及治疗提供参考。

Chronic spontaneous urticaria(CSU)is a common allergic skin disease in clinical practice.Its pathogenesis is complex and has not been fully elucidated.According to the popular theory of helper T lymphocyte 1(Th1)/Th2 cytokine imbalance in recent years,Th2 cytokines can directly or indirectly induce allergic diseases,and their abnormal secretion is closely related to the occurrence,development,and prognosis of CSU.In addition,in recent years,Th17 cytokines have also attracted the attention of researchers,and more and more evidence has shown that it plays an important role in CSU.The drug treatment for related cytokines has also made unprecedented progress.Therefore,this paper reviews the roles of Th2 and Th17-related cytokines in the occurrence and development of CSU,and provides references for subsequent research and treatment.