结核病流行现况及遗传易感性研究进展

Current situation of tuberculosis and research progress on its genetic susceptibility

结核病(tuberculosis,TB)是全球主要传染病死因之一,其传播广泛,并可侵犯全身各器官,对人类健康造成了巨大的威胁。TB发生发展受多因素影响,除传统的环境因素外,遗传多态性逐渐被人们重视,IFNG、P2X7、VDR等基因多态性已被发现与结核病易感性显著相关,相关研究势必为结核病预防和治疗带来新的思路。本文系统总结了结核病遗传易感性相关基因,为今后结核病预防提供参考。

Tuberculosis(TB)is one of the main causes of infectious diseases-related death in the whole world,which spreads worldwide and can invade widely all organs of the body,which poses a great threat to human health.Its occurrence and development are affected by many factors.Besides traditional environmental factors,genetic polymorphism has been paid more and more attention.Studies with interferon-γ(IFNG),P2X7,vitamin D receptor(VDR)and other gene polymorphisms have been found to be significantly associated with the susceptibility of tuberculosis,and related research is bound to bring new ideas for tuberculosis prevention and treatment.In this paper,we systematically summarizes the genes related to the genetic susceptibility of tuberculosis,providing reference for tuberculosis prevention in the future.