浙江省湖州地区初次献血人群HBsAg筛查策略研究

Study on HBsAg screening strategy among the first-time blood donors in Huzhou,Zhejiang Province

目的了解湖州地区初次献血人群乙肝表面抗原(HBsAg)阳性率状况,为制定精准筛查策略提供依据。方法对2019年1月至2021年12月期间的初次献血者,在健康检查合格后,采集末梢血进行HBsAg项目的筛查,从年龄和户籍不同维度对数据进行统计分析。结果本次研究共纳入初次献血人数为65354人,HBsAg初筛阳性率为0.63%(413/65354),其中男性和女性的初筛阳性率分别为0.68%(258/37905)和0.78%(215/27449),差异无统计学意义(χ^(2)=2.33,P>0.05)。不同年龄之间HBsAg初筛阳性率明显有差异(χ^(2)=68.56,P<0.05),阳性率最高的为46~55岁年龄组,最低的为18~25岁年龄组。外地户籍人口的HBsAg初筛阳性率明显高于本地户籍人口(χ^(2)=75.19,P<0.05)。18~25岁、26~35岁、36~45岁的本地户籍和外地户籍的HBsAg初筛阳性率比较,差异均有统计学意义(χ^(2)分别=20.30、91.93、14.62,P均<0.05),但46~55岁的本地户籍和外地户籍的HBsAg初筛阳性率比较,差异无统计学意义(χ^(2)=0.17,P>0.05)。结论随着年龄的下降,初次献血人群HBsAg阳性率明显下降;45岁以下各年龄组本地户籍人群的HBsAg阳性率均低于外地;对本地户籍35岁以下人群免做HBsAg项目的筛查是可行的。

Objective To analyze the positive rate of HBsAg among the first-time blood donors in Huzhou,and provide basis for formulating accurate screening strategies.Methods From January 2019 to December 2021,the first-time donors during this period were qualified for health examination,and their peripheral blood was collected for screening of HBsAg.Results In this study,65354 people participated in blood donation for the first time,and the positive rate of HBsAg was 0.63%(413/65354).The positive rate of primary screening for male and female was 0.68%(258/37905)and 0.78%(215/27449)respectively,and there was no significant difference between them(χ^(2)=2.33,P>0.05).The positive rate of HBsAg was significantly different among different ages(χ^(2)=68.56,P<0.05),the highest positive rate was in the group of 46-55 years old,and the lowest was in the group of 18-25 years old.The positive rate of HBsAg in non local registered residence people is significantly higher than that of local registered residence people(χ^(2)=75.19,P<0.05).There were statistically significant differences in the positive rate of HBsAg between the local registered residence and the non local registered residence who aged 18-25,26-35 and 36-45 years old(χ^(2)=20.30,91.93,14.62,P<0.05),but there was no significant difference in the positive rate of HBsAg between the local registered residence and the non local registered residence who aged 46-55(χ^(2)=0.17,P>0.05).Conclusion With the decline of age,the positive rate of HBsAg in the first-time blood donation population decreased significantly.The positive rate of HBsAg in the local registered residence people of all age groups below 45 years old was lower than that in non local registered residence people.It is not necessary to carry out HBsAg screening for local registered residence population who under 35 years old.