血清淀粉样蛋白A检测联合磁共振波谱、弥散张量成像在帕金森病患者认知功能障碍诊断中的应用

Serum amyloid A detection combined with magnetic resonance spectroscopy and diffusion tensor imaging in diagnosing cognitive impairment in Parkinson's disease

分析血清淀粉样蛋白A(SAA)检测联合磁共振波谱(MRS)、弥散张量成像(DTI)在帕金森病患者认知功能障碍诊断中的应用。研究发现观察组患者SAA明显高于对照组,且差异有统计学意义;联合诊断的敏感度、特异度、阳性预测值、阴性预测值及AUC均明显高于SAA、MRS及DTI单独应用,且差异存统计学意义。采用血清SAA检测联合MRS、DTI在帕金森病患者认知功能障碍诊断时可显著提高诊断敏感度及特异度,具有较高的诊断价值。

The purpose of this study was to evaluate the use of serum amyloid A(SAA)detection combined with magnetic resonance spectroscopy(MRS)and diffusion tensor imaging(DTI)in diagnosing cognitive impairment in patients with Parkinson's disease.The study showed that SAA level was significantly higher in the study group than that in the control group,with statistical difference.For diagnostic purpose,the sensitivity,specificity,positive predictive value,negative predictive value and AUC with combined use of SAA,MRS and DTI were significantly higher than those with SAA,MRS or DTI used alone,with statistical difference.In summary,SAA detection combined with MRS and DTI can significantly improve the sensitivity and specificity in identifying cognitive impairment in patients with Parkinson’s disease,showing a diagnostic performance.