复方谷氨酰胺联合四联疗法治疗消化性溃疡的临床研究

Clinical Study of Compound Glutamine Combined with Quadruple Therapy in the Treatment of Peptic Ulcer

目的:探讨复方谷氨酰胺联合四联疗法治疗消化性溃疡的临床研究。方法:选取我院在2019年3月到2022年3月收治的80例消化性溃疡患者作为研究对象。将患者分为常规组与联合组,每组40例。常规组采用四联疗法,联合组在对照组的基础上联合复方谷氨酰胺进行治疗。对比两组患者临床疗效与临床指标,碳13呼气试验、炎性因子水平变化、生活质量以及复发率。结果:在本次研究80例患者经碳13呼气试验,两组患者Hp阳性率对比无差异(P>0.05),治疗后两组患者Hp阳性率降低,且联合组低于常规组(P<0.05);治疗后,联合组总有效率为95%,常规组总有效率为75%,联合组优于常规组(P<0.05);治疗前,两组患者炎症因子水平对比无差异(P>0.05),治疗后,两组患者hs-CRP、IL-6、TNF-α水平均有所降低,且联合组优于常规组(P<0.05);治疗前,两组患者生活质量各维度评分比较无明显差异(P>0.05),治疗后两组患者各维度评分均有提升,且联合组高于常规组(P<0.05);疗程结束后对两组患者进行随访,联合组溃疡复发率为5%,常规组溃疡复发率为25%,联合组低于常规组(P<0.05)。结论:在临床治疗当中,采用复方谷氨酰胺联合四联疗法治疗,能够降低患者Hp阳性率,且能够有效降低机体炎性反应,提高患者生活质量水平,临床效果明显,且复发率低。

Objective:To investigate the clinical study of compound glutamine combined with quadruple therapy in the treatment of peptic ulcer.Methods:80 patients with peptic ulcer treated in our hospital from March 2019 to March 2022 were selected as the research objects.The patients were divided into routine group and combined group,with 40 cases in each group.The conventional group was treated with quadruple therapy,and the combined group was treated with compound glutamine on the basis of the control group.The clinical efficacy and clinical indicators,carbon 13 breath test,changes in inflammatory factor levels,quality of life and recurrence rate were compared between the two groups.Results:Before the carbon 13 breath test of 80 patients in this study,there was no significant difference in the positive rate of HP between the two groups(P>0.05).After treatment,the positive rate of HP in the two groups decreased significantly,and the combined group was lower than the conventional group(P<0.05);After treatment,the total effective rate was 95%in the combined group and 75%in the conventional group.The combined group was better than the conventional group(P<0.05);Before treatment,there was no significant difference in the level of inflammatory factors between the two groups(P>0.05).After treatment,hs CRP,IL-6,TNF-αThe combined group was better than the conventional group(P<0.05);Before treatment,there was no significant difference in the scores of each dimension of quality of life between the two groups(P>0.05).After treatment,the scores of each dimension of the two groups were improved,and the combined group was higher than the conventional group(P<0.05);After the course of treatment,the patients in the two groups were followed up.The ulcer recurrence rate in the combined group was 5%,and that in the conventional group was 25%.The ulcer recurrence rate in the combined group was lower than that in the conventional group(P<0.05).Conclusion:In clinical treatment,Compound Glutamine Combined with quadruple therapy can reduce the HP positive rate of patients,effectively reduce the inflammatory reaction of the body,and improve the quality of life of patients.The clinical effect is obvious,and the recurrence rate is low.