间歇性θ脉冲刺激联合有氧运动训练对老年2型糖尿病合并轻度认知功能障碍患者糖脂代谢、认知功能和听觉诱发电位P300的影响

Effects of Intermittent Theta Burst Stimulation Combined with Aerobic Exercise Training on Glucose and Lipid Metabolism,Cognitive Function and Auditory Evoked Potential P300 in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Mild Cognitive

目的:探讨间歇性θ脉冲刺激(i TBS)联合有氧运动训练对老年2型糖尿病(T2DM)合并轻度认知功能障碍(MCI)患者糖脂代谢、认知功能和听觉诱发电位P300的影响。方法:选取2020年3月~2021年11月期间来我院接受治疗的老年T2DM合并MCI患者117例。按照随机数字表法分为对照组(有氧运动训练,58例)和观察组(i TBS联合有氧运动训练,59例)。观察两组干预前后糖脂代谢、认知功能和听觉诱发电位P300的变化情况。结果:观察组干预后空腹血糖(FBG)、糖化血红蛋白(HbA1c)低于对照组(P<0.05)。两组干预后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)组间对比,统计学无差异(P>0.05)。观察组干预后蒙特利尔量表(MoCA)各维度及总分高于对照组(P<0.05)。观察组干预后中央区(Cz)潜伏期、组顶区(Pz)潜伏期短于对照组,Cz波幅、Pz波幅高于对照组(P<0.05)。结论:i TBS联合有氧运动训练用于老年T2DM合并MCI患者,可有效降低血糖,改善机体认知功能和听觉诱发电位P300。

Objective:To investigate the effects of intermittent theta burst stimulation(i TBS)combined with aerobic exercise training on glucose and lipid metabolism,cognitive function and auditory evoked potential(AEP)P300 in elderly patients with type 2 diabetes mellitus(T2DM)complicated with mild cognitive impairment(MCI).Methods:117 elderly patients with T2DM complicated with MCI who were treated in our hospital from March 2020 to November 2021 were selected.According to the random number table method,they were divided into control group(aerobic exercise training,58 cases)and observation group(i TBS combined with aerobic exercise training,59 cases).The changes of glucose and lipid metabolism,cognitive function and auditory evoked potential P300 in two groups before and after intervention were observed.Results:After intervention,the fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)in the observation group were lower than those in the control group(P<0.05).There were no statistical differences between the two groups after intervention in total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)(P>0.05).After intervention,the dimensions and total scores of Montreal scale(MoCA)in the observation group were higher than those in the control group(P<0.05).After intervention,the latency of central area(CZ)and parietal area(PZ)in the observation group were shorter than those in the control group,and the amplitude of CZ and PZ were higher than those in the control group(P<0.05).Conclusion:The i TBS combined with aerobic exercise training for elderly patients with T2DM complicated with MCI can effectively reduce blood glucose,improve cognitive function and auditory evoked potential P300.