海马保护在全脑放疗中的研究进展

Recent advances in hippocampal sparing whole brain radiotherapy

全脑放疗是脑转移患者及小细胞肺癌患者预防性照射的标准放疗方案,在提高肿瘤局部控制及延长总体生存期的同时,也造成了神经认知功能损伤。相关研究表明,在全脑放疗时进行海马保护,可以在一定程度上保护神经认知功能及提高生活质量。本文阐述了海马保护的方法、意义,并结合最新放疗技术和试验药物概括了海马保护相关的临床研究进展,对于目前存在的争议、问题进行总结探讨,以期为临床工作提供参考。

Whole brain radiotherapy(WBRT)is the standard radiotherapy regimen of preventive radiation for patients diagnosed with brain metastases and non-small cell lung cancer,which can improve intracranial control and prolong overall survival.However,neurocognitive functions(NCF)decline due to impaired hippocampal might occur thereafter.Recent studies have shown that hippocampal sparing WBRT(HS-WBRT)is capable of protecting neurocognitive function and improving quality of life(QOL).In this review,the authors described the methods and significance of hippocampal sparing,summarized the research progress on clinical trials related to HS-WBRT in combination with the development of radiotherapy technology and experimental drugs,and discussed the existing controversies and problems,aiming to provide reference for clinical work.