银杏二萜内酯葡胺注射液联合氯吡格雷治疗冠心病合并脑梗死的临床分析

Clinical Analysis of Ginkgo Biloba Diterpene Lactone Glucamine Injection Combined with Clopidogrel in the Treatment of Coronary Heart Disease with Cerebral Infarction

目的 观察冠心病合并脑梗死患者采用氯吡格雷联合银杏二萜内酯葡胺注射液治疗的临床效果。方法 对商丘市第一人民医院2020年3月至2022年3月间收治的80例脑梗死患者为研究对象,利用随机排列法分为参照组(氯吡格雷)与试验组(氯吡格雷和银杏二萜内酯葡胺注射液)各40例,均持续治疗3个月,比较各组间的中医证候积分、认知功能评分、血小板功能、有效率、不良反应。结果 两组研究对象治疗前中医证候积分和认知功能评分比较,差异无统计学意义(P>0.05);治疗后,两组中医证候积分均低于本组治疗前,认知功能评分均高于本组治疗前,差异有统计学意义(P<0.05);且试验组治疗后中医证候积分低于参照组,认知功能评分高于参照组,差异有统计学意义(P<0.05)。治疗前两组血小板黏附率、血小板聚集率、最大聚集时间和P-选择素浓度四项血小板功能指标比较,差异无统计学意义(P>0.05);治疗后,四项血小板功能指标水平均低于本组治疗前,差异有统计学意义(P<0.05),且试验组治疗后四项血小板功能指标水平均低于参照组,差异有统计学意义(P<0.05)。试验组治疗有效率(90.00%)高于参照组(72.50%),差异有统计学意义(P<0.05)。试验组不良反应发生率(15.00%)与参照组不良反应发生率(10.00%)相比,差异无统计学意义(P>0.05)。结论 氯吡格雷联合银杏二萜内酯葡胺注射液可在改善临床症状的同时调节机体的血小板功能,在促进患者认知功能的恢复的基础上提高整体治疗效果,不增加不良反应,临床应用价值显著。

Objective To observe the clinical effect of clopidogrel combined with ginkgo biloba diterpene lactone glucamine injection on patients with coronary heart disease complicated with cerebral infarction. Methods A total of 80 cerebral infarction patients admitted to the First People’s Hospital of Shangqiu City from March 2020 to March 2022 were studied. They were randomly divided into the control group(clopidogrel) and the experimental group(clopidogrel and ginkgo diterpene lactone glumine injection) with 40 cases each. All the patients were treated for 3 months. TCM syndrome score, cognitive function score, platelet function, effective rate and adverse reaction were compared among all groups. Results There was no significant difference in TCM syndrome scores and cognitive function scores between the two groups before treatment(P>0.05). After treatment, TCM syndrome scores in both groups were lower than before treatment, and cognitive function scores were higher than before treatment, the difference was statistically significant(P<0.05). After treatment, TCM syndrome score of experimental group was lower than that of reference group, and cognitive function score was higher than that of reference group, the difference was statistically significant(P<0.05). There was no statistical significance in platelet adhesion rate, platelet aggregation rate,maximum aggregation time and P-selectin concentration between the two groups before treatment(P>0.05). After treatment,the levels of four platelet function indexes were lower than before treatment in this group, the difference was statistically significant(P<0.05), and the levels of four platelet function indexes in experimental group were lower than those in the reference group after treatment, the difference was statistically significant(P<0.05). The effective rate of experimental group(90.00%) was higher than that of reference group(72.50%), and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the experimental group(15.00%) and the reference group(10.00%)(P>0.05). Conclusion Clopidogrel and Diterpene Ginkgolides Meglumine Injection can reduce the clinical symptoms, produce less impact on the adverse reactions, adjust the blood platelet function. On the basis of promoting the recovery of patients’ cognitive function, the overall therapeutic effect was improved without increasing adverse reactions, and the clinical application value was significant.