中西医结合治疗多囊卵巢综合征致复发性流产的效果观察

Observation on the therapeutic Effect of integrated traditional Chinese and Western Medicine on recurrent Abortion caused by polycystic Ovary Syndrome

目的 探讨中西医结合对多囊卵巢综合征所致复发性流产的治疗效果。方法 对90例于2016年6月至2018年6月前来河南省驻马店市中医院诊治的多囊卵巢综合征致复发性流产患者进行研究,经随机数字表法分组。对照组45例,用克罗米酚,观察组45例,联合使用补肾活血方,比较两组有效率、激素水平、胰岛功能、凝血功能、子宫动脉血流动力学和妊娠情况。结果 观察组治疗效果、排卵效果和妊娠成功率高于对照组,产生卵巢过度刺激综合征的概率低于对照组,差异有统计学意义(P<0.05);两组用药前激素水平、胰岛功能、凝血功能、子宫动脉血流动力学差异无统计学意义(P>0.05),观察组用药后黄体生成素、促卵泡激素、睾酮、空腹胰岛素、胰岛素抵抗指数、纤维蛋白原、收缩期峰值流速/舒张末期流速、阻力指数和搏动指数低于对照组,凝血时间、凝血酶原时间和活化部分凝血活酶审时间更长,胰岛素分泌指数高于对照组,差异有统计学意义(P<0.05)。结论 在多囊卵巢综合征致复发性流产治疗中应用中西医结合方案,效果明显,对患者胰岛功能、凝血功能和子宫动脉血流动力学均有改善作用,可通过对激素水平的调节来改善妊娠率结局。

Objective To explore the therapeutic effect of integrated traditional Chinese and western medicine on recurrent abortion caused by polycystic ovary syndrome. Methods A total of 90 patients with recurrent abortion caused by polycystic ovarian syndrome who came to Zhumadian Hospital of Traditional Chinese Medicine in Henan Province from June 2016 to June 2018 were studied and divided into groups by random number table. The control group(45 cases) was treated with clomiphene,and the observation group(45 cases) was treated with Bushen Huoxue Formula on the basis of the control group. The effective rate, hormone level, islet function, coagulation function, uterine artery hemodynamics and pregnancy were compared between the two groups. Results The treatment effect, ovulation effect and pregnancy success rate of the observation group were higher than those of the control group, and the probability of producing ovarian hyperstimulation syndrome was lower than that of the control group, the difference was statistically significant(P<0.05);There was no statistically significant difference in hormone level,islet function, coagulation function and uterine artery hemodynamics between the two groups before treatment(P>0.05). After treatment, luteinizing hormone, follicle-stimulating hormone, testosterone, fasting insulin, insulin resistance index, fibrinogen,systolic peak flow rate/end-diastolic flow rate, resistance index and pulsatility index in the observation group were lower than those in the control group, the coagulation time, prothrombin time and activated partial thromboplastin examination time were longer, and the insulin secretion index was higher than that of the control group, the difference was statistically significant(P<0.05). Conclusion In the treatment of recurrent abortion caused by polycystic ovary syndrome, the combination of traditional Chinese and western medicine has obvious effect. It can improve the pancreatic islet function, blood coagulation function and uterine artery hemodynamics of patients, and can improve the pregnancy outcome by regulating the hormone level.