TAB2/TAB3:炎症激活和调控的重要组件

TAB2/TAB3:Important Components Involved in the Activation and Regulation of Inflammation

TAK1结合蛋白2(TAK1 binding protein 2,TAB2)和TAK1结合蛋白3(TAK1 binding protein 3,TAB3)是转化生长因子β活化激酶1(transforming growth factor-β-activated kinase 1,TAK1)结合蛋白(TAK1 binding proteins,TABs)的两种同源蛋白,它们作为TAK1-TABs复合物的关键组成部分可介导激活丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)和核因子κB(nuclear factor kappa-B,NF-κB)信号级联,促进炎症反应的发生,并且TAB2/TAB3的表达水平及其翻译后修饰对炎症调控意义非凡,该文主要对上述过程中TAB2/TAB3的作用进行简述。

TAB2 (TAK1 binding protein 2) and TAB3 (TAK1 binding protein 3),two homologous proteins of TABs[TAK1 (transforming growth factor-β-activated kinase 1) binding proteins],as key components of the TAK1-TABs complex,mediate the activation of the MAPK (mitogen-activated protein kinase) and NF-κB (nuclear factor kappa-B) signaling cascades to promote the occurrence of inflammation.Moreover,the expression levels of TAB2/TAB3 and their post-translational modifications play an important role in the regulation of inflammation.This paper focuses on a brief review of the role of TAB2/TAB3 in the processes mentioned above.