DYRK1A在神经系统发育与疾病中的研究进展

Research Progress of DYRK1A in Nervous System Development and Disease

双特异性酪氨酸磷酸化调控激酶1A(dual specificity tyrosine phosphorylation regulated-kinase 1A,DYRK1A)是一种在进化上非常保守的蛋白激酶,对生物节律、糖原合成和细胞周期进程等生物过程具有重要的调控作用。近年来,越来越多的研究表明,DYRK1A还可调控神经元和胶质细胞的功能,参与唐氏综合征、自闭症、阿尔茨海默病和帕金森病等神经系统疾病的发生发展过程。该文系统地总结了近几年来DYRK1A蛋白在不同类型神经细胞中的功能,及其在神经系统疾病发病机制中的作用,旨在为针对该蛋白的研究提供有价值的信息。

DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) is a highly evolutionary conserved protein kinase.It plays an important role in regulating biological processes such as biothythm,glycogen synthesis and cell cycle progression.In recent years,more and more studies have shown that DYRK1A can also regulate the functions of neurons and glial cells,and participate in the pathologic processes of neurological diseases such as Down syndrome,autism,Alzheimer’s disease and Parkinson’s disease.This review systematically summarized the function of DYRK1A in different types of nerve cells and its role in the pathogenesis of nervous system in recent years,aiming to provide valuable information for the study of DYRK1A.