TGF-β及Smad家族在瘢痕疙瘩形成中作用的研究进展

Research Progress on the Role of TGF-β and Smad Family in Keloid Formation

瘢痕疙瘩是皮肤损伤后真皮中成纤维细胞过度增殖和细胞外基质过量沉积引起的皮肤纤维性良性肿瘤。其发病机制十分复杂,可能与遗传、免疫及细胞信号转导通路等有关,是目前临床上多发病之一。瘢痕疙瘩可以引起皮肤瘙痒、疼痛,影响人体美观及功能。因治疗后复发率高,其发病机制受到广大科研人员和医疗者的重视。研究显示,转化生长因子-β(TGF-β)对细胞的增殖、分化和免疫功能都有重要的调节作用,是瘢痕疙瘩形成的重要作用因子。该文将对TGF-β及在瘢痕疙瘩形成中具有作用的Smad的相关研究进行概述,并探究瘢痕疙瘩的发病机制。

Keloid is a benign fibrous tumor of the skin caused by excessive proliferation of fibroblasts and excessive deposition of extracellular matrix in the dermis after skin injury.The pathogenesis is complex,which may be related to genetic,immune and cellular signal transduction pathways.Keloid is one of the frequently occurring diseases in clinic.Keloid scar can not only influence beauty,but also are often accompanied with picking pain,pruritus and even cause dysfunction.Due to the high recurrence rate after treatment,more and more researchers pay attention to the molecular mechanism of the keloid.Some studies have shown that TGF-β (transforming growth factor-β) is an important effective factor for the formation of keloid,which plays an important role in the regulation of cell proliferation,differentiation and immune function.In this paper,a correlative research on the relationship of TGF-β and Smad in keloid formation were summarized,and the pathogenesis of keloid was explored.