摘要
Dear Editor,Microvascular damage is a pivotal pathological factor in lower limb ischemia/reperfusion(I/R)injury.1 Excessive reactive oxygen species(ROS)formation and disrupted autophagic flux have been recognized as the critical mechanism of cellular death,2,3 especially in I/R injury.Recent investigation has displayed that fibroblast growth factor 21(FGF21)exerts a protective effect against I/R injury via transcription factor EB(TFEB)-mediated autophagy and regulation of anti-oxidative response.4 However,the promising role of FGF21 in acute lower limb I/R injury remains elusive.
基金
National Natural Science Foundation of China(81972150,82172428 To J.X.)
Key scientific and technological innovation projects of Wenzhou(ZY20200023 To J.X.)
Wenzhou Inovation Team(Growth factor drug development,No.201801)
CAMS Innovation Fund for Medical Sciences(2019-I2M-5-028).
