富血小板血浆联合热敏灸治疗慢性局限性湿疹80例

Treating 80 cases of chronic regional eczema with platelet-rich plasma plus heat-sensitive moxibustion

目的:观察富血小板血浆(Platelet-rich Plasma,PRP)联合热敏灸治疗慢性局限性湿疹的临床疗效,初步明确治疗机制。方法:将80例慢性局限性湿疹患者随机分为对照组与治疗组各40例,对照组采用复方氟米松软膏治疗;治疗组采用PRP联合热敏灸治疗,两组均治疗21 d。比较两组患者治疗前、治疗后第1天及治疗后第60天皮损,包括不同部位皮损症状严重程度,所占面积的大小、瘙痒程度进行综合评分,取湿疹面积及严重程度指数(Eczema Area and Severity Index,EASI)评分和视觉模拟评分法(Visual Analogue Scale,VAS)评分的总和评分进行疗效评价。结果:两组治疗后第1天各皮损项目评分较治疗前下降(P<0.05),治疗组各皮损项目评分下降幅度优于对照组(P<0.05);治疗组治疗后第60天各皮损项目评分较治疗前仍有明显下降(P<0.05),对照组各皮损项目评分较治疗前无明显下降(P>0.05);治疗组近期、远期疗效总有效率均高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:PRP联合热敏灸治疗能够在行气通络、活血除湿的同时起到促进组织修复,加速疮面愈合,抗炎抗菌的作用,显著降低慢性局限性湿疹皮损评分,改善皮损症状,且复发率低、治疗时间短、经济负担小,可有效改善患者的生活质量,值得临床进一步推广。

Objective:To observe the clinical effect of platelet-rich plasma plus heat-sensitive moxibustion in the treatment of chronic regional eczema,and to preliminarily clarify the treatment mechanism.Methods:A total of 80 patients with chronic regional eczema were randomly divided into the control group and the treatment group,the control group was given compound flumetasone ointment treatment,while the treatment group received platelet-rich plasma plus heat-sensitive moxibustion treatment,both groups were treated for 21 days.The skin lesions in the two groups were compared before treatment,1 day after treatment and 60 days after treatment.The severity of skin lesions in different parts,the size of the area occupied and the degree of pruritus were comprehensively scored.The total score of EASI score and VAS score were used to evaluate the efficacy.Results:On the first day after treatment,the score of the lesion was decreased(P<0.05).The decrease of the score in the treatment group was better than the control group(P<0.05),but there was no significant difference between the two groups(P>0.05).In the treatment group,the score of the lesion was decreased significantly(P<0.05)on the 60th day after treatment,and the score in the control group had no significant decrease(P<0.05).The short-term and longterm efficacy rates in the treatment group were higher than the control group.And there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Platelet-rich plasma plus heat-sensitive moxibustion can reduce the score of chronic regional eczema significantly,relieve the symptoms of skin lesions,decrease the recurrence rate,shorten the treatment time,and improve the patient’s life quality,therefore this method is worthy of being applied more extensively.