基于数据挖掘的27位国医大师治疗更年期综合征用药规律分析

Analysis of the medication rules of 27 Chinese medicine masters in the treatment of menopausal syndrome based on the ancient and modern medical case cloud platform

目的:通过数据挖掘的方法探究国医大师治疗更年期综合征的用药规律,以为临床治疗提供参考。方法:检索、收集国医大师治疗更年期综合征的医案数据,建立标准化医案数据库,对医案数据进行规范化处理,并利用古今医案云平台(V2.3.5),对中药频次统计、中药属性分析、聚类分析与复杂网络分析等进行统计分析。结果:最终纳入27位国医大师185诊次医案。中药频次结果显示共得到高频中药前五种为白芍、茯苓、枸杞子、甘草、当归等,药性多为平、温,药味以甘为主,药物多归于肝、肾经;经聚类及复杂网络分析发现核心方剂为二仙汤、四君子汤、逍遥散和左归饮。结论:国医大师治疗更年期综合征擅长肝脾肾三脏同调,以固肾为本,兼以柔肝健脾,调和气血,养阴育阳。

Objective:To explore the prescription rules of traditional Chinese medicine masters for the treatment of menopausal syndrome through data mining,so as to provide reference for clinical treatment.Methods:Retrieve and collect medical record data of traditional Chinese medicine masters for treatment of menopausal syndrome,establish a standardized medical record database,standardize medical record data,and use the data mining function of Ancient and Modern Medical Case Cloud Platform(V2.3.5)to count the frequency of traditional Chinese medicine,statistic analysis of traditional Chinese medicine attribute analysis,cluster analysis and complex network analysis.Results:The final inclusion of the 27 national masters of medicine 185 consultation times medical cases.The frequency results of traditional Chinese medicine showed that the top five high-frequency traditional Chinese medicines were Baishao(Redix Paeoniae Alba),Fuling(Poria),Goqizi(Fructus Lycii),Gancao(Radix et Rhizoma Glycyrrhizae),Danggui(Radix Angelicae Sinensis).The properties of the medicine were mostly mild and warm,and the taste was mainly sweet.The medicines were mostly attributed to the liver and kidney meridians;after clustering and complex network analysis,the core formulas were found to be the Erxian decoction(二仙汤),the Sijunzi decoction(四君子汤),Xiaoyao San(逍遥散)and Zuogui Yin(左归饮).Conclusion:Masters of traditional Chinese medicine in treating menopausal syndrome are good at coordinating the three organs of liver,spleen and kidney,focusing on strengthening the kidney,softening the liver and strengthening the spleen,reconciling Qi(气)and blood,and nourishing Yin and Yang(阴阳).