基于数据研究现代岭南名医喘证组方用药规律

A study on the medication rule of TCM on asthma syndrome by Lingnan famous modern doctors based on data mining

目的:探索现代岭南名医治疗喘证的临床组方原则及用药特色。方法:收集岭南名医治疗喘证案例51例,提取方药信息,利用Excel 2010、SPSS 25.0等予药物频数、用药类别、聚类等分析,进行数据挖掘。结果:(1)频数分析:甘草、半夏、苦杏仁、茯苓、五味子等33味药物为高频药物。前4味常用岭南特色草药为陈皮、桂枝、鱼腥草、枇杷叶。药类频数居前5位的为化痰止咳平喘药、补虚药、清热药、解表药、利水渗湿药。(2)聚类分析:C1:干姜、细辛、白芍、桂枝、五味子;C2:白芥子、莱菔子、桃仁、厚朴;C3:白术、党参、茯苓、甘草;C4:紫菀、桔梗、百部、半夏、陈皮、苏子、款冬花;C5:麦冬、黄芪;C6:黄芩、葶苈子;C7:冬瓜子、芦根、鱼腥草、薏苡仁;C8:麻黄、石膏、苦杏仁;C9:栝楼、桑白皮;共9组药物组合。结论:通过数据挖掘方法得出岭南名医治疗喘证的常用药物、类别及不同组合,为现代中医治疗岭南地区喘证病患提供了新的思路和方法。

Objective: The clinical prescription principles and medication characteristics of Lingnan famous modern doctors in treating asthma syndrome were explored. Methods: A total of 51 medical cases of Lingnan famous doctors were collected, the prescription data was extracted, and drug frequency, medication category and clustering were analyzed by Excel 2010 and SPSS 25.0. Results:(1)Frequency analysis: A total of 33 drugs including Gancao(Radix Glycyrrhizae), Banxia(Rhizoma Pinelliae),Kuxingren(Semen Armeniacae Amarum), Fuling(Poria), Wuweizi(Fructus Schisandrae Chinensis)were high-frequency drugs. The first 4 commonly used Lingnan characteristic medicines were Chenpi(Pericarpium Citri Reticulatae);Guizhi(Ramulus Cinnamomi);Yuxingcao(Herba Houttuyniae);Pipaye(Folium Eriobotryae). The top 5 drugs in frequency are phlegm, cough and asthma medicine, deficiency medicine, antipyretic medicine, anti-table medicine, and water and moisture infiltration medicine.(2)Cluster analysis: C1: Ganjiang(Rhizoma Zingiberis), Xixin(Asari Radix et Rhizoma);Baishao(Radix Paeoniae Alba);Guizhi(Ramulus Cinnamomi);Wuweizi;Laifuzi(Semen Raphani);Taoren(Semen Persicae);Houpo(Cortex Magnoliae Officinalis);Dangshen(Radix Salviae Miltiorrhizae);Fuling;Gancao;C4: Ziwan(Radix Asteris);Jiegeng(Radix Platycodonis);Baibu(Radix Stemonae);Banxia;Chenpi;Suzi(Fructus Perillae);Kuandonghua(Flos Farfarae);C5: Maidong(Radix Ophiopogonis);Huangqi(Radix Astragali);C6: Huangqin(Radix Scutellariae);Tinglizi(Semen Lepidii);C7: Dongguazi(Semen Benincasae);Lugen(Rhizoma Phragmitis);Yuxingcao;Yiyiren(Semen Coicis);C8: Mahuang(Herba Ephedrae);Shigao(Gypsum Fibrosum);Kuxingren;C9: Gualou(Fructus Trichosanthis);Sangbaipi(Cortex Mori);there were 9 drug combinations. Condusion: Through data mining methods, the common drugs, categories and different combinations of Lingnan famous doctors are obtained, which provides new ideas and methods for modern traditional Chinese medicine to treat asthma patients in Lingnan region.