伴失眠的缓解期抑郁症患者客观睡眠质量与认知功能的关系研究

Relationship Between Objective Sleep Quality and Cognitive Function in Rremission Depression Patients with Insomnia

目的:分析抑郁症缓解期合并失眠患者自身认知功能及其睡眠质量的相关性。方法:选取2019年10月至2021年10月福州市长乐区精神病医院精神科收治的抑郁症缓解期患者60例作为研究对象,按是否存在睡眠障碍分为观察组和对照组,每组30例。对照组患者睡眠正常,观察组患者合并失眠存在睡眠障碍,比较睡眠质量、认知功能,进行睡眠与认知功能相关性分析以及多因素回归分析。结果:睡眠质量比较,观察组较差,对照组较好(P<0.05);认知功能比较,观察组即刻记忆表现较差(P<0.05);相关性分析显示,患者夜间总清醒时长与延迟记忆功能负相关(P<0.05),患者REM持续与注意力正相关(P<0.05),患者REM期占比与注意力、即刻记忆正相关(P<0.05);多因素回归分析显示,夜间清醒总时长以及REM期占比可显著影响延迟记忆、注意力,在认知功能相关影响因素中属于独立影响因素。结论:抑郁症缓解期患者睡眠质量对患者认知功能具有一定相关性,尤其是夜间总清醒时间与REM期占比,是认知功能独立影响因素。

Objective:To analyze the correlation between cognitive function and sleep quality in patients with depression in remission and insomnia.Methods:A total of 60 patients in remission of depression admitted to the psychiatric Department of Changle District Psychiatric Hospital of Fuzhou City from October 2019 to October 2021 were selected as research objects and divided into observation group and control group according to whether there were sleep disorders,with 30 cases in each group.Patients in the control group had normal sleep,while patients in the observation group were complicated with insomnia and had sleep disorders.Compared with sleep quality and cognitive function,correlation analysis and multivariate regression analysis were conducted between sleep and cognitive function.Results:The sleep quality of the observation group was worse than the control group(P<0.05).Compared with cognitive function,the immediate memory performance of the observation group was worse(P<0.05).Correlation analysis showed that the total awake duration at night was negatively correlated with delayed memory function(P<0.05),the duration of REM was positively correlated with attention(P<0.05),and the proportion of REM was positively correlated with attention and immediate memory(P<0.05).Multi-factor regression analysis showed that the total duration of waking at night and the proportion of REM could significantly affect delayed memory and attention,which were independent factors among the factors related to cognitive function.Conclusion:Sleep quality has a certain correlation with cognitive function in patients with depression in remission,especially the proportion of total awake time at night and REM period,which is an independent factor affecting cognitive function.