噻托溴铵联合多索茶碱治疗慢性阻塞性肺病的疗效及对睡眠质量的影响

Effect of Tiotropium Bromide Combined with Doxofylline on Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease

目的:探究噻托溴铵与多索茶碱联用治疗慢性阻塞性肺病的疗效及对睡眠质量的影响。方法:选取2021年6月至2022年6月枣庄市峄城区人民医院收治的慢性阻塞性肺病患者120例作为研究对象,按照随机数字表法随机分为对照组与观察组,每组60例。2组患者入院后随即给予对症治疗,其中对照组患者给予多索茶碱治疗,观察组则在对照组治疗基础上联合噻托溴铵治疗,统计分析2组患者临床疗效、不良反应发生率;观察2组患者治疗前后肺功能指标和睡眠质量。结果:治疗后,观察组临床总有效率91.7%,高于对照组的81.7%,2组比较差异有统计学意义(P<0.05);2组患者FEV 1、PEF、FVC以及FEV 1/FVC水平高于治疗前,观察组患者各项肺功能指标均优于对照组,2组比较差异有统计学意义(P<0.05);观察组总不良反应发生率低于对照组,差异有统计学意义(P<0.05);2组患者PSQI评分、夜间觉醒次数、睡眠潜伏期、REM睡眠潜伏期、REM睡眠期比例和总睡眠时间较治疗前均有所改善,观察组各项指标均优于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:噻托溴铵联合多索茶碱治疗慢性阻塞性肺病能提高临床疗效,降低不良反应发生率,提升患者肺功能,改善睡眠质量。

Objective:To investigate the effect of tiotropium bromide combined with doxofylline on chronic obstructive pulmonary disease(COPD)and sleep quality.Methods:A total of 120 patients with chronic obstructive pulmonary disease admitted to Yicheng District People′s Hospital of Zaozhuang City from June 2021 to June 2022 were selected as the research objects,and were divided into control group and observation group according to the random number table method,with 60 patients in each group.The two groups of patients were given symptomatic treatment immediately after admission.The patients in the control group were treated with doxofylline,and the patients in the observation group were treated with tiotropium bromide on the basis of the treatment in the control group.The clinical efficacy and adverse reaction rate of the patients in the two groups were statistically analyzed;Pulmonary function and sleep quality were observed before and after treatment.Results:After treatment,the total clinical effective rate in the observation group was 91.7%,which was higher than that in the control group(81.7%).The difference between the two groups was statistically significant(P<0.05);The levels of FEV 1,PEF,FVC and FEV 1/FVC in the two groups were higher than those before treatment,and the lung function indexes of the patients in the observation group were better than those in the control group.The difference between the two groups was statistically significant(P<0.05);The total adverse reaction rate in the observation group was lower than that in the control group,with a statistically significant difference(P<0.05);PSQI score,nocturnal arousal times,sleep latency,REM sleep latency,REM sleep phase ratio and total sleep time of patients in the two groups were improved compared with those before treatment.All indicators in the observation group were better than those in the control group,and there were significant differences between the two groups(all P<0.05).Conclusion:Tiotropium bromide combined with doxofylline in the treatment of chronic obstructive pulmonary disease can improve the clinical efficacy,reduce the incidence of adverse reactions,improve pulmonary function and improve sleep quality.