2015-2019年某三甲医院成人侵袭性假丝酵母病监测结果

Analysis of surveillance results of hospital associated invasive candidiasis in Grade-A tertiary hospital from 2015 to 2019

目的了解某三级甲等医院2015-2019年间医院内侵袭性假丝酵母病(HAIC)的流行病学特点,初步探索HAIC的危险因素,为HAIC的防控提供依据。方法参照统一的诊断标准进行HAIC诊断。通过收集该院2015-2019年间HAIC确诊病例的临床信息,包括患者年龄、性别、科室等临床流行病学资料和感染菌株、感染部位等感染特征,分析2015-2019年间该医院HAIC发生的流行病学特点。结果2015-2019年间该院住院成人患者(住院时长>48 h)共281205例,共发生了130例HAIC,发病率为0.46‰。男性患者HAIC的发病率高于女性患者(P<0.05);老年患者HAIC的发病率高于年轻患者(P<0.05);HAIC的高发科室为ICU(P<0.05)。致病菌株主要为白假丝酵母(69/130,53.08%),主要感染部位前两位分别为血流感染(54/130,41.54%)和腹(盆)腔感染(50/130,38.46%)。结论HAIC的主要感染菌株为白假丝酵母,主要感染部位为血流感染。男性患者和老年患者可能是发生HAIC的高风险人群,ICU可能是发生HAIC的高风险科室。

OBJECTIVE To investigate the characteristics of the epidemiology of hospital associated invasive candidiasis(HAIC)in a Grade-A tertiary hospital from 2015 to 2019,and to explore the risk factors for HAIC,so as to provide evidence for the prevention and control of HAIC.METHODS HAIC was diagnosed according to the unified diagnostic criteria.The clinical information of HAIC confirmed cases in this hospital from 2015 to 2019 were collected,including the patient′s age,gender,department and other clinical epidemiological data and infection characteristics such as infection strain and infection site.The epidemiological characteristics of HAIC in the hospital from 2015 to 2019 were analyzed.RESULTS From 2015 to 2019,there were a total of 281205 adult patients(hospitalization duration>48h)in the hospital.HAIC occurred in 130 patients,with an incidence rate of 0.46‰.The incidence of HAIC in male patients was higher than that in female patients(P<0.05);the incidence of HAIC in elderly patients was higher than that in young patients(P<0.05);the high incidence department of HAIC was ICU(P<0.05).The pathogenic strains were mainly Candida albicans(69/130,53.08%).The first two main infection sites were bloodstream infections(54/130,41.54%).and abdominal(pelvic)infection(50/130,38.46%).CONCLUSION The main pathogenic strain of HAIC is Candida albicans,and the main infection site is bloodstream infection.Male patients and elderly patients are high-risk groups for HAIC,and ICU is a high-risk department for HAIC.