慢性阻塞性肺疾病合并呼吸系统曲霉菌感染研究进展

Progress of chronic obstructive pulmonary disease complicated with respiratory system Aspergillus infection

慢性阻塞性肺疾病(COPD)的急性加重常与细菌和病毒感染有关,但是曲霉菌感染与COPD的进展关系仍不明确。虽然COPD是呼吸道曲霉感染疾病发生的危险因素,但从曲霉菌定植进展为侵袭性感染的潜在机制仍不确定。近年来,分子技术的发展已经使研究者对呼吸道真菌感染的病理生理、临床诊断、治疗预后有了进一步的认识。真菌生物组测序揭示了呼吸道曲霉菌感染在COPD病程中的作用,包括与临床表现、疾病进展和病死率的关系。本文探讨COPD合并曲霉菌感染的不同类型、诊断方法以及治疗策略的新进展,以期为临床工作提供借鉴。

Chronic obstructive pulmonary disease(COPD)exacerbations of are often associated with bacterial and viral infections.However the relationship between Aspergillus infection and COPD progression remains unclear.Although COPD is a risk factor for the development of respiratory Aspergillus disease,the underlying mechanisms of progression from Aspergillus colonization to invasive infection remain unclear.In recent years,the development of molecular technology has enabled us to understand the pathophysiology,clinical diagnosis,treatment and prognosis of respiratory fungal infections.Fungal biome sequencing reveals the role of respiratory Aspergillus infection in the course of COPD,including the association with clinical manifestations,disease progression,and mortality.In this article,we discussed the progressive research of different types of COPD complicated with Aspergillus infection on diagnostic methods and treatment strategies,in order to provide reference for clinical.