脂肪间充质干细胞外囊泡促进创面血管生成机制的研究进展

Research advances on the mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis

创面愈合涉及复杂的病理生理学机制,其中血管生成被认为是创面愈合的关键步骤之一,促进创面血管生成可以加速创面愈合。近年来,间充质干细胞来源的细胞外囊泡被证明可产生与干细胞疗法相当的促创面愈合效果,且具有低抗原性、更好的生物相容性等优点。关于细胞外囊泡促创面愈合的具体机制目前仍不完全清楚,被认为涉及创面愈合的各个阶段。该文主要对脂肪间充质干细胞外囊泡在促进创面血管生成中的可能机制进行阐述,为进一步研究细胞外囊泡促进创面愈合的机制提供思路。

Wound healing involves complex pathophysiological mechanism,among which angiogenesis is considered as one of the key steps in wound healing,and promoting wound angiogenesis can accelerate wound healing.In recent years,mesenchymal stem cell-derived extracellular vesicles have been proven to produce equivalent effects of wound healing promotion comparable to stem cell therapy,with the advantages of low antigenicity and high biocompatibility.The specific mechanism by which extracellular vesicles facilitate wound healing is still not fully understood and is thought to involve all stages of wound healing.This article focuses on the possible mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis,so as to provide ideas for further study on the mechanism of extracellular vesicles to promote wound healing.