核转录因子红系2相关因子2在创面愈合中的作用研究进展

Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing

创面愈合是机体常见的病理生理过程之一。如何改善创面愈合条件,使创面快速愈合,一直是研究的热点。氧化应激是影响创面愈合的重要因素之一。核转录因子红系2相关因子2(Nrf2)是一种经典的抗氧化应激因子,也是极具潜力的促创面愈合因子。Nrf2的激活可以调控下游的抗氧化应激元件,发挥抗细胞凋亡、维持细胞稳态的作用,从而改善创面的愈合环境,促进创面的修复。该文概述了Nrf2常见的激动剂及抑制剂,并综述了Nrf2促进糖尿病溃疡、辐射损伤、缺血再灌注损害等皮肤创面愈合的作用。

Wound healing is one of the common pathophysiological processes in the body.How to improve the condition of wound healing to promote rapid wound healing has always been a hotspot in research.Oxidative stress is one of the important factors affecting wound healing.Nuclear factor-erythroid 2-related factor 2(Nrf2)is a classic antioxidant stress factor as well as a factor with great potential in facilitating wound healing.The activation of Nrf2 can regulate the downstream antioxidant stress elements and play roles of anti-apoptosis and cell homeostasis maintaining,which improves wound healing environment and promotes wound repair.This paper summarized the common agonists and inhibitors of Nrf2 and reviewed the roles of Nrf2 in promoting skin wound healing including diabetic ulcers,radiation injury,and ischemia-reperfusion injury,etc.