摘要
轮状病毒(rotavirus,RV)是引起人类和动物急性胃肠炎的重要病原体。结构蛋白VP8*(viral protein 8*,VP8*)位于RV最外层的刺突状VP4的头部,VP8*在受体识别和结合中发挥重要作用。目前对RV受体结合特性的研究主要集中在A组轮状病毒(group A rotavirus,RVA)和C组轮状病毒(group C rotavirus,RVC)。本文对RV的蛋白结构、受体类型以及RVA和RVC受体结合特性及与受体相互作用的结构基础等研究进展进行综述。
Rotavirus(RV)is important pathogen causing acute gastroenteritis in humans and animals.Viral protein 8*(VP8*)is located in the head of VP4 in the outermost layer of RV.VP8*plays an important role in receptor recognition and binding.At present,the research on the binding characteristics of RV receptor mainly focuses on group A rotaviruses(RVA)and group C rotaviruses(RVC).This paper reviews the protein structure and receptor types of RV,as well as the receptor binding characteristics of RVA and RVC and the structural basis of their interaction with receptors.
作者
王铭月
孙晓曼
李丹地
Wang Mingyue;Sun Xiaoman;Li Dandi(NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,China CDC,Beijing 102206,China;School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2022年第6期748-752,共5页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金(21934005)。