阻塞性睡眠呼吸暂停低通气综合征患者认知障碍与脑灰质区改变研究进展

Research progress on cognitive dysfunction and brain gray matter areas changes in patients with obstructive sleep apnea hypopnea syndrome

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是睡眠过程中各种原因导致上呼吸道阻塞引起的睡眠呼吸障碍, 目前对于OSAHS的诊断和治疗存在不足。OSAHS由于睡眠呼吸紊乱引起过度氧化应激和炎性反应导致认知功能下降, 其脑灰质区改变可能与认知功能障碍相关。文中旨在探讨OSAHS患者认知障碍与脑灰质区改变的相关性及其内在机制, 为临床早期诊断和治疗提供理论依据。

Obstructive sleep apnea hypopnea syndrome(OSAHS)is a sleep breathing disorder caused by obstruction of the upper airway during sleep from various causes.At present,the diagnosis and treatment of OSAHS are insufficient.OSAHS causes cognitive decline due to excessive oxidative stress and inflammatory response caused by sleep breathing disorder,and its alteration of the brain gray matter area may be related to cognitive dysfunction.This review investigates the correlation between cognitive dysfunction and brain gray matter areas changes in OSAHS,and elucidates the underlying mechanisms,which provide a theoretical basis for early clinical diagnosis and treatment.