眼动指标应用于阿尔茨海默病中医辨证的可行性探讨

Feasibility of Eye Movement Measures in Chinese Medicine Syndrome Differentiation of Alzheimer’s Disease

以中医学“目脑相关”为切入点,从物质基础、功能、经络三方面对目与脑的生理病理关系进行总结,认为阿尔茨海默病(AD)发病与目、脑密切相关,以肾精不足为本、精衰而脑消目呆;病位在脑、脑损神乱而视瞻异常;以脑络病变贯穿始终、脑络损及目络。以此作为眼动指标能够应用于AD辨证诊断的理论基础,同时通过梳理眼动指标在AD诊断及中医辨证中的研究现状,针对眼动指标可前移AD诊断窗口、能够反映中医证候、有助于中医诊断及疗效评价客观化等优势进行探讨,以探索眼动指标应用于AD中医辨证诊断的可行性。

This paper summarized the physiological and pathological relationship between the eye and the brain from three aspects including the material basis,function,and meridians-collaterals,by taking the “eye-brain correlation” in traditional Chinese medicine(TCM) as the starting point.The onset of Alzheimer disease(AD) is closely related to the abnormal function of the eye and the brain.The root of the disease is kidney essence insufficiency with essence desertion,there is brain decline and glazed eyes.The disease location of AD is at brain,and there is brain damage,mental disorder,and abnormal vision.Brian collaterals damage exists throughout the whole process of AD,which can cause eye collaterals damage.Based on the theory mentioned above,this paper puts forward that eye movement measures can be used for syndrome differentiation and diagnosis of AD.Moreover,its feasibility has been discussed by summarizing the current research situation of the usage of eye movement measures in TCM syndrome differentiation and diagnosis of AD,and by discussing the advantages in moving the AD diagnosis window forward,reflecting the TCM syndrome,and promoting the objectification of TCM diagnosis and effect evaluation.