活血方剂防治骨科术后静脉血栓栓塞症的机制研究进展

Research Progress in Mechanism of Promoting Blood Circulation Prescription in Prevention and Treatment of Venous Thromboembolism After Orthopedic Surgery

静脉血栓栓塞症(VTE)的病因病机与“气血不和”密切相关,活血方剂对VTE的形成相关因素(D-二聚体分子、血小板、炎症因子、凝血酶及血管内皮细胞等因素)具有正向调控作用。活血方剂可有效活跃纤溶系统,降低D-二聚体分子水平,减轻血管内皮细胞的损伤、炎症反应,抑制凝血酶活性、血小板聚集及炎症因子释放,改善血小板功能及血液高凝状态,恢复血管内皮细胞功能,从而预防VTE的形成。

The etiology and pathogenesis of venous thromboembolism(VTE)is closely related to the‘disharmony between Qi and blood’.Promoting blood circulation prescription has a positive regulatory effect on the formation of VTE related factors(D-dimer molecules,platelets,inflammatory factors,thrombin and vascular endothelial cells).Promoting blood circulation prescription can effectively activate the fibrinolytic system,reduce the level of D-dimer molecule,reduce the damage of vascular endothelial cells,inflammatory reaction,inhibit thrombin activity,platelet aggregation and inflammatory factor release,improve platelet function and blood hypercoagulability,restore vascular endothelial cell function,so as to prevent the formation of VTE.