脑心通胶囊联合单硝酸异山梨酯、尼可地尔治疗不稳定型心绞痛的临床疗效

Efficacy of Naoxintong capsule combined with isosorbide mononitrate and nicorandil in treating unstable angina pectoris

目的 分析脑心通胶囊联合单硝酸异山梨酯、尼可地尔治疗不稳定型心绞痛(UAP)的疗效。方法 选取我院2019年1月—2020年10月诊治的UAP患者96例作为研究对象,采用随机数字表法分成对照组及研究组,每组48例。对照组患者在常规治疗基础上接受单硝酸异山梨酯、尼可地尔治疗,研究组患者在对照组基础上加用脑心通胶囊治疗,比较2组患者临床疗效、不良反应及治疗前后血清8-羟基脱氧鸟苷(8-OHdG)、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)、胰岛素样生长因子-1(IGF-1)、超敏C反应蛋白(hs-CRP)水平。结果 研究组患者总有效率为95.83%,高于对照组的79.17%(P<0.05)。治疗前,2组患者血清IGF-1、hs-CRP、T-AOC、SOD、8-OHdG、MDA水平比较,差异均无统计学意义(P>0.05)。治疗后,2组患者血清IGF-1、T-AOC、SOD水平高于治疗前,且研究组高于对照组(P<0.05);2组患者血清hs-CRP、8-OHdG、MDA水平低于治疗前,且研究组低于对照组(P<0.05)。研究组患者治疗期间不良反应发生率为18.75%,低于对照组的22.92%,但差异并无统计学意义(P>0.05)。结论 脑心通胶囊联合单硝酸异山梨酯、尼可地尔治疗UAP效果显著,可改善血清IGF-1、hs-CRP水平,调节氧化应激反应,且安全性较好,值得推广。

Objective To analyze the therapeutic efficacy of Naoxintong capsule combined with isosorbide mononitrate and nicorandil on unstable angina pectoris(UAP).Methods Ninety-six patients with UAP diagnosed and treated in our hospital from January 2019 to October 2020 were selected as the study participants.They were assigned to the control group and the experimental group by the random number table,with 48 cases in each group.The control group received isosorbide mononitrate and nicorandil based on conventional treatment,and the experimental group received Naoxintong capsules based on the control group.The clinical efficacy,adverse reactions,and serum 8-hydroxydeoxyguanosine mononitrate(8-OHdG),total antioxidant capacity(T-AOC),superoxide dismutase(SOD),malondialdehyde(MDA),insulin-like growth facto r-1(IGF-1),and high-sensitivity C-reactive protein(hs-CRP) levels before and after treatment were compared between the two groups.Results The overall response rate of the experimental group was 95.83%,which was higher than that of the control group(79.17%)(P <0.05).Before treatment,there were no significant differences in serum IGF-1,hs-CRP,T-AOC,SOD,8-OHdG,and MDA levels between the 2 groups(P>0.05).After treatment,the serum IGF-1,T-AOC,and SOD levels in the two groups were significantly higher than those before treatment,and the experimental group was higher than the control group(P<0.05).The serum hs-CRP,8-OHdG and MDA levels in the two groups were significantly lower than those before treatment,and the experimental group was lower than the control group(P<0.05).The incidence rate of adverse reactions during treatment in the experimental group was 18.75%,which was lower than that in the control group(22.92%),without statistical significance(P>0.05).Conclusion Naoxintong capsule in combination with isosorbide mononitrate and nicorandil is effective in the treatment of UAP,which can improve the serum IGF-1 and hs-CRP levels and regulate oxidative stress,with a good safety profile.These benefits hold promise for a wider application of this procedure.