益经护巢汤对卵巢功能减退性不孕症患者性激素、炎症因子及妊娠结局的影响

Effect of Yijing Huchao Tang on Sex Hormones,Inflammatory Factors and Pregnancy Outcomes in Patients with Infertility Due to Diminished Ovarian Reserve

目的:观察益经护巢汤对卵巢功能减退性(DOR)不孕症患者性激素、炎症因子及妊娠结局的影响。方法:将100例DOR不孕症患者按随机数字表法分为对照组48例和研究组52例,对照组给予常规西药治疗,研究组在对照组基础上给予益经护巢汤治疗。比较2组治疗前后血清性激素水平、炎症因子水平、细胞因子水平、中医证候积分以及卵巢超声检查结果,并随访1年,统计2组妊娠结局。结果:研究组妊娠率61.54%,高于对照组41.67%(P<0.05);研究组流产率1.92%,低于对照组10.42%,2组比较,差异无统计学意义(P>0.05)。治疗前,2组血清雌二醇(E2)、睾酮(T)、促黄体生成素(LH)、促卵泡生成素(FSH)水平比较,差异无统计学意义(P>0.05);治疗后,2组E2水平均升高(P<0.05),T、LH水平均降低(P<0.05),研究组FSH水平降低(P<0.05);且研究组E2水平高于对照组(P<0.05),T、LH、FSH水平低于对照组(P<0.05)。治疗前,2组各中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组各中医证候积分均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗前,2组子宫内膜厚度和窦卵泡数比较,差异无统计学意义(P>0.05);治疗后,2组子宫内膜厚度和窦卵泡数均升高(P<0.05),且研究组高于对照组(P<0.05)。治疗前,2组白细胞介素-21(IL-21)、白细胞介素-10 (IL-10)、白细胞介素-4 (IL-4)水平比较,差异无统计学意义(P>0.05);治疗后,2组IL-21水平降低(P<0.05),IL-10、IL-4水平升高(P<0.05),且研究组IL-21水平低于对照组(P<0.05),IL-10、IL-4水平高于对照组(P<0.05)。结论:益经护巢汤用于DOR不孕症患者的治疗中可促进患者卵巢功能恢复,改善机体免疫功能,提高妊娠率,从而改善临床症状和妊娠结局。

Objective:To observe the effect of Yijing Huchao Tang on sex hormones,inflammatory factors and pregnancy outcomes in patients with infertility due to diminished ovarian reserve(DOR).Methods:A total of 100 cases of patients with infertility due to DOR were divided into the control group and the study group according to the random number table method,with 48 and 52 cases in each group respectively.The control group was treated with routine western medicine,and the study group was additionally treated with Yijing Huchao Tang based on the treatment of the control group.Before and after treatment,the levels of sex hormones in serum,inflammatory factors and cytokines,the Chinese medicine syndrome scores and the ultrasound examination results of ovarian in the two groups were compared.After one-year follow-up,the pregnancy outcomes in the two groups were counted.Results:The pregnancy rate was 61.54% in the study group,higher than that of 41.67% in the control group(P0.05).Before treatment,there was no significant difference being found in the comparison of levels of estrogen(E2),testosterone(T),luteinizing hormone(LH) and follicle stimulating hormone(FSH) between the two groups(P>0.05).After treatment,the E2levels in the two groups were increased(P0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased(P0.05).After treatment,the endometrial thickness and number of antral follicle in the two groups were increased(P0.05).After treatment,the IL-21 levels in the two groups were decreased(P<0.05),and the levels of IL-10 and IL-4 were increased(P<0.05);the IL-21 level in the study group was lower than that in the control group(P<0.05),and the levels of IL-10 and IL-4 were higher(P<0.05).Conclusion:Yijing Huchao Tang for patients with infertility due to DOR can improve their recovery of ovarian function,improve immune function in the body and pregnancy rates,so as to improve the clinical symptoms and pregnancy outcomes.