结直肠癌合并原发性肝癌双原发癌的临床特征分析:附40例报告

Characteristics of dual primary carcinoma involving colorectal and hepatic carcinoma:A retrospective analysis of 40 cases

目的研究结直肠癌(CRC)合并原发性肝癌(PHC)双原发癌患者的临床病理特征,并分析影响患者预后的危险因素。方法回顾性分析2012年7月至2021年6月中山大学附属第六医院40例CRC合并PHC双原发癌患者的临床病理资料,并结合随访资料进行生存分析。结果40例中有23例(57.5%)同时性双原发癌和17例(42.5%)异时性双原发癌患者,两组发病年龄和临床病理特征比较,差异无统计学意义。随访14(2~81)个月,31例生存,患者2年生存率为77.6%,5年生存率为61.0%。第一原发癌为CRC的患者(27例)和第一原发癌为PHC的患者(13例)生存时间比较,差异无统计学意义(P=0.346)。第一原发癌种类、发病年龄、发病间隔以及是否存在CRC相关基因突变对患者预后的影响差异无统计学意义。结论对于CRC合并PHC双原发癌患者,第一原发癌种类、发病年龄、发病间隔以及是否存在CRC相关基因突变不是影响患者预后的独立危险因素。

Objective To investigate the clinicopathologic characteristics,treatment modalities,prognosis and risk factors in patients with dual primary carcinoma involving colorectal carcinoma(CRC)combined with primary hepatic carcinoma(PHC).Methods The clinicopathologic and follow-up data of 40 cases with dual primary CRC and PHC in the Sixth Affiliated Hospital,Sun Yat-sen University from July 2012 to June 2021 were retrospectively analyzed.Results Among the 40 cases,23 cases(57.5%)were diagnosed with simultaneous dual primary cancer and 17(42.5%)with metachronous dual primary cancer.There were no significant differences in age of onset and clinicopathological characteristics between the two groups.After 14 months(ranging from 2 to 81 months)of follow-up,31 cases survived.The 2-,5-year survival rate was 77.6%,61.0%respectively.The difference in overall survival between patients with CRC as the first primary cancer(27 cases)and patients with PHC as the first primary cancer(13 cases)was not statistically significant(P=0.346).There were no significant differences in the type of the first primary cancer,age of onset,interval of onset and the presence of CRC-related gene mutation on the prognosis of patients.Conclusion For patients with dual primary CRC and PHC,the type of the first primary cancer,age of onset,interval of onset,and the presence of CRC-related gene mutation are not independent risk factors affecting the prognosis of patients.